Peer reviewed scientific papers

Dufailu OA, JMahdavi J, Ala’Aldeen DAA, Wooldridge KG, Oldfield NJ (2018). Uptake of Neisserial autotransporter lipoprotein (NalP) promotes an increase in human brain microvascular endothelial cell metabolic activity. Microbial pathogenesis 124, 70-75

Azimi S, Wheldon LM, Oldfield NJ, Ala’Aldeen DAA, Wooldridge KG (2018). A role for Fibroblast Growth Factor Receptor 1 in the pathogenesis of Neisseria meningitidis. BioRxiv, 283028.

Oldfield NJ, Harrison OB, Bayliss CD, Maiden MC, Ala'Aldeen DA, Turner DP (2016). Genomic Analysis of Serogroup Y Neisseria meningitidis Isolates Reveals Extensive Similarities Between Carriage-Associated and Disease-Associated Organisms. J Infect Dis. 213:1777-85.

Oldfield NJ, Rojas E, Hoyos J, Lee P, Flint M, Jones CH, Ala’Aldeen DAA (2015). Optimization of molecular approaches to genogroup Neisseria meningitidis carriage isolates and implications for monitoring the impact of new serogroup B vaccines. Public Library of Science.

Rojas E, Hoyos J, Oldfield NJ, Lee P, Flint M, Jones CH, Ala'Aldeen DAA, Jansen KU, Anderson AS (2015). Optimization of Molecular Approaches to Genogroup Neisseria meningitidis Carriage Isolates and Implications for Monitoring the Impact of New Serogroup B Vaccines. PLoS ONE. 10:e0132140.

Khairalla AS, Omer SA, Mahdavi J, Aslam A, Dufailu OA, Self T, Jonsson AB, Geörg M, Sjölinder H, Royer PJ, Martinez-Pomares L, Ghaemmaghami AM, Wooldridge KG, Oldfield NJ, Ala'Aldeen DAA (2015) Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters. Cellular Microbiology.17:1008-20.

Alqahtani F, Mahdavi J, Wheldon LM, Vassey M, Pirinccioglu N, Royer PJ, Qarani SM, Morroll S, Stoof J, Holliday ND, Teo SY, Oldfield NJ, Wooldridge KG, Ala'Aldeen DAA (2014) Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis. Open Biology. 4. pii: 140053.

Alamro M, Bidmos FA, Chan H, Oldfield NJ, Newton E, Bai X, Aidley J, Care R, Mattick C, Turner DPJ, Neal KR, Ala’Aldeen DAA, Feavers I, Borrow R, Bayliss CD (2014). Phase Variation Mediates Reductions in Expression of Surface Proteins During Persistent Meningococcal Carriage. Infect Immun. 82; 2472-84

Mahdavi J, Pirinccioglu N, Oldfield NJ, Carlsohn E, Stoof J, Aslam A, Self T, Cawthraw SA, Petrovska L, Colborne N, Sihlbom C, Borén T, Wooldridge KG, Ala'Aldeen DAA. (2014). A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization. Open Biology. 22;4:130202.

Zorman JK, Esser M, Raedler M, Kreiswirth BN, Ala’Aldeen DAA, Kartsonis N, Smugar SS, Anderson A, McNeely T and Arduino JM (2013). Naturally Occurring IgG Antibody Levels to the Staphylococcus aureus Protein IsdB in Humans. Human Vaccines & Immunotherapeutics. 9:1857-64.

Snyder LA, Loman NJ, Faraj LA, Levi K , Weinstock G, Boswell TC , Pallen MJ, Ala’Aldeen DAA (2013). Epidemiological investigation of Pseudomonas aeruginosa isolates from a six-year-long hospital outbreak using high-throughput whole genome sequencing. Eurosurveillance. 18 (42) :pii=20611

Mahdavi J, Royer P-J, Sjölinder HS, Azimi S, Self T, Stoof J, Wheldon LM, Brännström K, Wilson R, Moreton J, Moir JWB, Sihlbom C, Borén T, Jonsson A-B, Soultanas S, Ala’Aldeen DAA. (2013). Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence. Open Biology. 3, 130048

Royer P-J, Rogers AJ, Wooldridge KG, Tighe PJ, Mahdavi J, Rittig MG, and Ala'Aldeen DAA (2013). Deciphering the contribution of human meningothelial cells to the inflammatory / antimicrobial response at the meninges. Infect Immun. 81:4299-310

Oldfield NJ, Matar S, Bidmos FA, Alamro M, Neal KR, Turner DPJ, Bayliss CD & Ala’Aldeen DAA (2013). Prevalence and phase variable expression status of two autotransporters, NalP and MspA, in carriage and disease isolates of Neisseria meningitidis. PLoS ONE 8, e69746.

Abouseada NM, Assafi MSA, Mahdavi J, Oldfield NJ, Wheldon LM, Wooldridge KG and Ala'Aldeen DAA. (2012) Mapping the laminin receptor binding domains of Neisseria meningitidis PorA and Haemophilus influenzae OmpP2. PLoS ONE 7. e46233

Ibraz-Pavon AB, MacLennan J, Andrews NJ, Gray SJ, Urwin R, Clarke SC, Walker AM, Evans MR, Kroll JS, Neal KR, Ala’Aldeen DAA, Crook DW, Cann K, Harrison S, Cunningaham R, Baxter D, Kaczmarski E, McCarthy ND, Jolley KA, Cameron JC, Stuart JM and Maiden MCJ. 2011. Changes In Serogroup And Genotype Prevalence Among Carried Meningococci In The United Kingdom During Vaccine Implementation. J Infect Dis. 204, 1046-53

Ala'Aldeen DAA, Oldfield NJ, Bidmos FA, Abouseada NM, Ahmed NW, Turner DPJ, et al. (2011) Carriage of meningococci by university students, United Kingdom. Emerg Infect Dis, 17, 1761-1763.

Tauseef I, Harrison OB, Wooldridge KG, Feavers IM, Neal KR, Gray SJ, Kriz P, Turner DPJ, Ala’Aldeen DAA, Maiden MCJ, and Bayliss CB. (2011) Influence of the Combination and Phase Variation Status of the Haemoglobin Receptors, HmbR and HpuAB, on Meningococcal Virulence. Microbiology. 157:1446-56.

Bidmos F, Neal KR, Oldfield NJ, Turner DPJ, Ala’Aldeen DAA and Bayliss CD (2011). Rapid Clonal Expansion, Persistence and Clonal Replacement of Meningococcal Carriage Isolates in a 2008 University Student Cohort. J Clin Microbiol. 49, 506-512.

Tunio SA, Oldfield NJ, Ala’Aldeen DAA, Wooldridge KG and Turner DPJ (2010). The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells. BMC Microbiology. 10: 280-

Tunio SA, Oldfield NJ, Berry A, Ala'Aldeen DAA, Wooldridge KG & Turner DPJ (2010) The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis : surface localization and role in host cell adhesion. Mol. Microbiol. 76 , 605-615.

Ala’Aldeen DAA, Flint M, Oldfield NJ, Omer SA, McNeil LK, Jiang Q, Murphy E, Giardina PC, Novikova EG, Dodge IL, Bayliss CD, Turner DPJ, Neal KR, Hoiseth SK, Jansen KU and Anderson AS. (2010) Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage. Vaccine, 28: 7667-6675.

Oldfield NJ, Worrall KE, Rycroft AN, Ali T, Wooldridge and Ala'Aldeen DAA (2009) AasP autotransporter protein of Actinobacillus pleuropneumoniae does not protect pigs against homologous challenge. Vaccine 27:5278-83

Orihuela C, Mahdavi J, Thornton J, Mann B, Wooldridge KG, Abouseada N, Oldfield NJ, Self T, Ala’Aldeen DAA, Tuomanen EI. (2009) Laminin receptor initiates contact of bacterial with the blood brain barrier in experimental meningitis models. J Clin Invest. 2009 119: 1638-1646. (joint senior author)

Bacterial break-in: Research Highlights. (2009) Nature. 459: p487: 28 May 2009 (highlight of the JCI paper)

Li Y, Wooldridge KG, Javed MA, Tang C and Ala’Aldeen DAA (2009) Secreted proteins of Neisseria meningitidis protect mice against infection. Vaccine. 27:2320-5

Spence PR, Wright V, Ala’Aldeen DAA, Turner DPJ, Wooldridge KG Wooldridge and James R (2008) Validation of a Virulence and Epidemiology (VirEp) DNA microarray for Staphylococcus aureus. J Clin Microbiol. 46, 1620-1627.

Ali T, Oldfield NJ, Wooldridge KG, Turner DPJ, and Ala'Aldeen DAA (2008) Functional characterization of AasP, a maturation protease autotransporter protein of Actinobacillus pleuropneumoniae. Infect. Immun. 76, 5608-5614.

Maiden MCJ, Ibarz-Pavón AB, Urwin R, Gray SJ, Andrews NJ, Clarke SC, Walker AM, Evans MR, Kroll JS, Neal KR, Ala'Aldeen DAA, Crook DW, Cann K, Harrison S, Cunningham R, Baxter D, Kaczmarski E, MacLennan J, Cameron JC, Stuart JM. (2008) Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity. J Infect Dis, 197:737-743.

Oldfield NJ, Donovan EA, Worrall KE, Wooldridge KG, Langford PR, Rycroft AN, Ala'Aldeen DAA (2008). Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae. Vaccine. 26, 1942-1954.

Ashgar SA, Oldfield NJ, Wooldridge KG, Jones MA, Irving GJ, Turner DPJ & Ala’Aldeen DAA (2007). CapA, an autotransporter protein of campylobacter jejuni, mediates association with human epithelial cells and colonization of the chicken gut. J. Bacteriol. 189: 1856–1865.

Oldfield NJ, Bland SJ, Taraktsoglou M, Dos-Ramos F, Robinson K, Wooldridge KG & Ala’Aldeen DAA (2007) T-cell stimulating protein a (TspA) of Neisseria meningitidis is required for optimal adhesion to human cells. Cell Microbiol. 9, 463–478.

Turner DPJ, Marietou AG. Johnston L, Ho KKL, Rogers AJ, Wooldridge KG & Ala’Aldeen DAA (2006). Characterisation of MspA - an immunogenic autotransporter protein mediating adhesion to epithelial and endothelial cells in Neisseria meningitides. Infect Immun 74, 2957–2964

Wooldridge KG, Kizil M , Wells DB & Ala’Aldeen DAA (2005) Unusual Genetic Organization of a Functional Type I Protein Secretion System in Neisseria meningitidis. Infect Immun. 73, 5554–5567

Robinson K, Wooldridge KG, Wells D, Dos Ramos F, Hasan A, Todd I, Robins A, James R & Ala’Aldeen DAA (2005). T-Cell-Stimulating Protein A Elicits Immune Responses during Meningococcal Carriage and Human Disease. Infect Immun. 8, 4684–4693

Robinson K, Taraktsoglou K, Rowe K, Wooldridge KG & Ala’Aldeen DAA (2004). Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation. Cell Microbiol . 6, 927–938

Constantin D, Cordenier A, Robinson K, Ala'Aldeen DAA, Murphy S (2004) Neisseria meningitidis‑induced death of cerebrovascular endothelium: mechanisms triggering transcriptional activation of inducible nitric oxide synthase". J Neurochem. 89, 1166‑1174.

Goulding JN, Stanley J, Olver W, Neal KR, Ala'Aldeen DAA and Arnold C (2003), Independent subsets of amplified fragments from the genome of Neisseria meningitidis identify the same invasive clones of ET37 and ET5 J Med Microbiol, 52, 151-154

Bebb JR, Bailey-Flitter N, Ala’Aldeen DAA and Atherton JA (2003) Mastic gum has no effect on Helicobacter pylori load in vivo. J Antimicrob Chemother 52, 522-523

Loughlin MF, Ala’Aldeen DAA and Jenks P (2003) Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice. J Antimicrob Chemother. 51:367-71

Turner DPJ, Wooldridge KG & Ala’Aldeen DAA (2002) Autotransported serine protease (AusP) of Neisseria meningitidis: a B-cell immunogenic, surface-exposed outer-membrane and secreted protein. Infect Immun, 70; 4447-4461.

Maiden et al (2002) Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccinatino. Lancet 359. 1829-30

Constantin D, Ala'Aldeen DAA, Murphy S (2002) Transcriptional activation of nitric oxide synthase-2, and NO-induced cell death, in mouse cerebrovascular endothelium exposed to N. meningitidis. J Neurochem 81; 270-276.

Ala'Aldeen DAA, KR Neal, A English & PM Hawkey (2002). Isolation of a serogroup 29E meningococcal strain carrying group-C siaD capsular gene. J Infect 44; 56-57.

Robinson K, KR Neal, C Howard, J Stockton, K Atkinson, E Scarth, J Moran, A Robins, I Todd, E Kaczmarski, S Gray, I Muscat, R Slack & DAA Ala’Aldeen. (2002). Characterisation of humoral and cellular immune responses elicited by meningococcal carriage. Infect Immun 70; 1301-9.

Abdel Hadi H, Wooldridge KG, Robinson K & Ala’Aldeen DAA. (2001) Identification and Characterisation of App: an Immunogenic Autotransporter Protein of Neisseria meningitidis. Mol Microbiol. 41; 611-624.

Turner PC, Thomas CE., Stojiljkovic I, Elkins C, Kizel G, Ala'Aldeen, DAA and Sparling PF (2001). Neisserial TonB‑dependent outer‑membrane proteins: detection, regulation and distribution of three putative candidates identified from the genome sequences. Microbiology 147: 1277‑1290

Wells D, Teigh P, Wooldridge KG, Robinson K & Ala’Aldeen DAA (2001). Differential gene expression during meningeal-meningococcal interaction: evaluation for self-defence and early release of cytokines and chemokines. Infec Immu, 69; 2718-2722.

Goulding JN, Hookey JV, Stanley J, Olver W, Neal KR, Ala’Aldeen DAA, Arnold C. (2000). Fluorescent amplified-fragment length polymorphism genotyping of Neisseria meningitidis identifies clones associated with invasive disease. J Clin Microbiol; 38, 4580-4585.

Ait-Tahar K, KG Wooldridge, D Turner, M Atta, I Todd & DAA Ala’Aldeen (2000) Auto-transporter A (AutA) protein of Neisseria meningitidis: a potent CD4+ T-cell and B-cell stimulating antigen detected by expression cloning. Mol Microbiol. 37; 1094-1105

Ala'Aldeen DAA, KR Neal, K Ait-Tahar, JS Nguyen-Van-Tam, A English, TJ Falla, PM Hawkey, RCB Slack. (2000) Dynamics of meningococcal long-term carriage among University students and their implications on mass-vaccination. J Clin Microbiol,. 38:2311-2316.

Kizil G, KE Wilks , DB Wells & DAA Ala'Aldeen. (2000) Identification and Characterisation of the Genes encoding Glyoxalase I and II of Neisseria meningitidis and Neisseria gonorrhoeae. J Med Microbiol 49; 669-673.

Neal KR, JS Nguyen-Van-Tam, N Jeffrey, RCB Slack, R Madeley, K Job, K Ait-Tahar, MCJ Wale & DAA Ala'Aldeen. (2000) Changing carriage rate of Neisseria meningitidis among university students during the first week of term. Cross sectional study. BMJ; 320, 846-849.

Neal KR, JS Nguyen-Van-Tam, RCB Slack, EB Kaczmarski, A White & DAA Ala’Aldeen. (1999) Seven week interval between acquisition of a meningococcus and the onset of invasive disease. Epidemiol Infect. 123: 507-9.

Kizil G, I Todd , M Atta, SP Borriello, K Ait-Tahar & DAA Ala’Aldeen. (1999) Identification and characterisation of TspA, a major CD4+ T-cell and B-cell stimulating Neisseria-specific antigen. Infect Immun. 67; 3533-3541.

Huwez FU, D Thirwell, A Cockayne DAA Ala’Aldeen. (1998) Mastic gum kills Helicobacter pylori. New Eng J Med. 339 1946.

Powell NBL, Bishop K, Palmer HM, Ala'Aldeen DAA, Gorringe AR and Borriello SP (1998) Differential binding of apo and holo human transferrin to meningococci and co-localisation of the transferrin binding proteins (TbpA and TbpB). J Med Microbiol 47, 257-264.

Pintor M, Ferrón C, Gomez JA, Powell NBL, Ala'Aldeen DAA, Borriello SP, Criado1 MT and Ferreirós CM. (1996) Blocking of Iron Uptake from Transferrin by Antibodies Against the Transferrin Binding Proteins in Neisseria meningitidis. Microb Pathog; 20, 127-139.

Ala'Aldeen DAA, Westphal AH, de Kok A, Weston V, Atta M, Baldwin TJ, Bartley J, and Borriello SP (1996). Cloning, Sequencing, Characterisation and implications on vaccine design of the Novel Dihydrolipoyl Acetyltransferase of Neisseria meningitidis. J Med Microbiol ; 45, 419-432.

Ala'Aldeen DAA and Borriello SP. (1996) The meningococcal transferrin-binding proteins 1 and 2 are both surface exposed and generate bactericidal antibodies capable of killing homologous and heterologous strains. Vaccine , 13, 49-53.

Ala’Aldeen DAA. A microbiologist's guide to travelers abroad: do as I say not as I do. J Hosp Infect. 35, 255-257

Ala’Aldeen DAA, Stevenson P, Griffiths E, Gorringe A, Iron L, Robinson A, Hyde S, and Borriello SP. (1994) Immune response in humans and animals to meningococcal transferrin-binding proteins: implications for vaccine design. Infect Immun 62: 2984-2900.

Ala’Aldeen DAA, Davies HA, Wall RA, Borriello SP. (1994) The 70 kilodalton iron regulated protein of Neisseria meningitidis: studies on surface exposure and functional attributes of common epitopes. Vaccine, 12: 535-541.

Bhatt R, Ala’Aldeen DAA, Baldwin T, and Borriello SP. (1994) The 126 Kilodalton protein of Listeria monocytogenous is not a transferrin binding protein. FEMS Microbiol Lett, 123: 119-124.

Atta M, Lim KL, Ala’Aldeen DAA, Powell RJ, Todd I. (1994) Detection of anti-fibronectin antibodies in systemic lupus erythematosus. Ann Rheum Dis 54: 117-124.

Ala’Aldeen, DAA, Powell NBL, Wall RA, Borriello SP. (1993). Localisation of the meningococcal receptors for human transferrin. Infect Immun. 61: 751-759.

Ala’Aldeen, DAA, Borriello SP, Griffiths E. (1993). Alteration of transfer ribonucleic acid of Neisseria meningitidis following growth in the presence of human transferrin. J Med Microbiol. 38: 442-448.

Wilton J, Ala’Aldeen DAA, Palmer HM, Borriello SP. (1993). Cloning and partial sequence of transferrin-binding protein 2 of Neisseria meningitidis using a novel method:Twin N-terminal PCR. FEMS Microbiol Lett. 107: 59-66.

Griffiths E, Stevenson P, Byfeild P, Ala’Aldeen DAA, Borriello SP, Holland J, Parsons T, and Williams P. (1993) Antigenic relationship of transferrin binding proteins from Neisseria meningitidis, N. gonorrhoeae, and Haemophilus influenzae: Cross-reactivity of antibodies to NH2 terminal peptides. FEMS Microbiol Lett, 109: 85-92.

Palmer HM, Powell NBL, Ala’Aldeen DAA, Wilton J and Borriello SP. (1993). Neisseria meningitidis transferrin-binding protein 1 expressed in Escherichia coli is surface exposed and binds human transferrin. FEMS Microbiol Lett. 110: 139-146.

Ala’Aldeen DAA, Wall RA, Borriello SP. (1990) Immunogenicity and cross-reactivity of the 70-kDa iron-regulated protein of Neisseria meningitidis in man and animals. J Med Microbiol. 32: 275-281.

Ala’Aldeen DAA, Davies HA, Wall RA, Borriello SP. (1990) The 70-kDa iron-regulated protein of Neisseria meningitidis is not the receptor for human transferrin. FEMS Microbiol Lett 69: 37-42.

Ala’Aldeen DAA and Barer MR (1989) Bacterial growth and toxin production in ileostomy effluents. J Med Microbiol. 28: 287-290.